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The rats were euthanized, and tissue samples (brain, heart, kidneys, liver, spleen, lung, stomach, intestine, muscle, grease, ovaries, womb, testicles, and thymus) were collected at 3 min, 10 min, 1 h, and 24 h after administration (three males and three females at each time point)

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Second, it shifts melanin synthesis away from eumelanin (the darker brown-black pigment) toward phaeomelanin (a lighter yellow-pink pigment)

In a drug-resistant tumor model in nude mice, quercetin treatment significantly reduced tumor weight and volume, with protein expression patterns consistent with in vitro findings